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Calling All Dogs with DCM for Research Study
D ilated Cardiomyopathy (DCM), a late-onset heart condition that can affect dog breeds such as Dober- man Pinschers, Boxers, Great Danes, Newfoundlands, Irish Wolfhounds, and English Cocker Spaniels, is a disease of the cardiac muscle that prevents the heart from func- tioning properly. When caught early, DCM may respond to medi- cal management, slowing the progression of the disease. However, DCM can often lead to congestive heart failure. Embark Veterinary has teamed up with Hill’s Pet Nutrition on the largest research study to date inves- tigating genetic risk factors that may lead to Dilated Cardiomyopathy. Leveraging our research-grade geno- typing platform, our goal is to develop a first-of-its- kind genetic test to help dog owners and veterinarians identify the potential risk of developing DCM, which can aid early detection and medical intervention. If your dog has been diagnosed with DCM, we urge you to participate by going to hillsembarkstudy.com. WHO CAN PARTICIPATE IN THE STUDY? The goal of the study is to genetically test 1,000+ dogs affected by DCM—the largest sample size studied to date and the first to include any and all breeds as well as mixed-breed dogs. Embark is actively recruiting dogs that have been diagnosed with DCM through echocardiography performed by a cardiologist. (Please Note: Dogs simply need to be diagnosed with DCM to qualify, there are no requirements regarding prior DCM-related genetic testing or suspicion of a nutritional component.) Respondents will be selected after a full review of medical and nutritional history and clinical data. Our findings will be published in an open-access journal so everyone can benefit from the research. QUALIFYING PARTICIPANTS WILL RECEIVE: • A complimentary Embark DNA Kit , including health, trait, and COI analysis. (Embark provides a free cheek swab with prepaid shipping). All owner and dog information is kept confidential. • Post-Study Results — Embark strives to publish in open- access journals. • Future Opportunities — Participate in new studies on canine health. GET STARTED NOW To see if your dog is eligible to participate, just complete this brief survey at www.hillsembarkstudy.com .
WHAT WE KNOW ABOUT DCM • Causes: Although the cause(s) of canine DCM is
unclear, there is evidence that genetics and nutrition are key to its development and progression. There are two known genetic variants (PDK4 and TTN) that may predispose dogs in certain populations of Doberman Pinschers to DCM. While Embark’s research is digging deeper into the reason some dogs with one or both of these variants develop DCM and some do not, Embark is also looking at multiple dog breeds to determine other causative variants. • Clinical Signs: Dogs with DCM may have decreased oxygen in the blood, causing lethargy, weakness, weight loss, and/or collapse. If there is also congestion of fluid in the lungs (congestive heart failure), dogs may experi- ence coughing, increased respiratory rate and/or effort, or abdominal distention. Dogs with DCM may also be predisposed to the development of cardiac arrhythmias. • Diagnosis: DCM is diagnosed by echocardiography, which is an ultrasound of the heart. Electrocardiog- raphy (EKG) may also be used to characterize heart rhythm and to identify arrhythmias. • Treatment: Oral or injectable cardiac medications can be given in an effort to improve heart function and con- trol arrhythmias, if present. Unfortunately, DCM can only be managed; there is no known cure at this time.
120 | SHOWSIGHT MAGAZINE, OCTOBER 2021
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